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One‐Pot Approach to Well‐Defined Biomolecular Assemblies by Orthogonal Chemoselective Ligations
Author(s) -
Galibert Mathieu,
Dumy Pascal,
Boturyn Didier
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200806223
Subject(s) - cycloaddition , alkyne , oxime , regioselectivity , click chemistry , combinatorial chemistry , azide , scaffold , chemistry , organic chemistry , computer science , catalysis , programming language
Click–click cyclopeptides : Well‐defined biomolecular assemblies are synthesized using orthogonal oxime bond formation and copper(I)‐mediated alkyne–azide cycloaddition reactions in a stepwise or in a one‐pot approach. To illustrate this strategy, regioselective ligation of biologically relevant peptides onto a cyclopeptidic scaffold was performed.