One‐Pot Approach to Well‐Defined Biomolecular Assemblies by Orthogonal Chemoselective Ligations | Zendy

Galibert Mathieu | Zendy; Dumy Pascal | Zendy; Boturyn Didier | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

One‐Pot Approach to Well‐Defined Biomolecular Assemblies by Orthogonal Chemoselective Ligations

Author(s) -

Galibert Mathieu,

Dumy Pascal,

Boturyn Didier

Publication year - 2009

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200806223

Subject(s) - cycloaddition , alkyne , oxime , regioselectivity , click chemistry , combinatorial chemistry , azide , scaffold , chemistry , organic chemistry , computer science , catalysis , programming language

Click–click cyclopeptides : Well‐defined biomolecular assemblies are synthesized using orthogonal oxime bond formation and copper(I)‐mediated alkyne–azide cycloaddition reactions in a stepwise or in a one‐pot approach. To illustrate this strategy, regioselective ligation of biologically relevant peptides onto a cyclopeptidic scaffold was performed.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research