A Different Approach to Enantioselective Organic Synthesis: Absolute Asymmetric Synthesis of Organometallic Reagents | Zendy

Lennartson Anders | Zendy; Olsson Susanne | Zendy; Sundberg Jonas | Zendy; Håkansson Mikael | Zendy

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A Different Approach to Enantioselective Organic Synthesis: Absolute Asymmetric Synthesis of Organometallic Reagents

Author(s) -

Lennartson Anders,

Olsson Susanne,

Sundberg Jonas,

Håkansson Mikael

Publication year - 2009

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200806222

Subject(s) - enantioselective synthesis , reagent , organic synthesis , chemistry , group 2 organometallic chemistry , combinatorial chemistry , organic chemistry , catalysis , molecule

Voilà, optical activity : Both enantiomers of 1‐chloroindene have been synthesized in high selectivity from solely achiral starting materials, and without using optically active catalysts (see scheme). These symmetry‐breaking syntheses provide a proof‐of‐concept for a new approach to asymmetric synthesis. NCS= N ‐chlorosuccinimide.

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