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A Different Approach to Enantioselective Organic Synthesis: Absolute Asymmetric Synthesis of Organometallic Reagents
Author(s) -
Lennartson Anders,
Olsson Susanne,
Sundberg Jonas,
Håkansson Mikael
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200806222
Subject(s) - enantioselective synthesis , reagent , organic synthesis , chemistry , group 2 organometallic chemistry , combinatorial chemistry , organic chemistry , catalysis , molecule
Voilà, optical activity : Both enantiomers of 1‐chloroindene have been synthesized in high selectivity from solely achiral starting materials, and without using optically active catalysts (see scheme). These symmetry‐breaking syntheses provide a proof‐of‐concept for a new approach to asymmetric synthesis. NCS= N ‐chlorosuccinimide.