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Complete Chiral Resolution Using Additive‐Induced Crystal Size Bifurcation During Grinding
Author(s) -
Noorduin Wim L.,
van der Asdonk Pim,
Meekes Hugo,
van Enckevort Willem J. P.,
Kaptein Bernard,
Leeman Michel,
Kellogg Richard M.,
Vlieg Elias
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200806214
Subject(s) - grinding , bifurcation , resolution (logic) , materials science , mathematics , composite material , physics , computer science , nonlinear system , artificial intelligence , quantum mechanics
Grinding them down: By using a tailor‐made additive, even in the absence of racemization in solution, abrasive grinding can yield an enantiopure solid state. This novel chiral resolution technique is based on an asymmetric bifurcation in the crystal size distribution as a result of stereoselective hampered crystal growth. R= o ‐tolyl.