Allosteric Switches: Remote Controls for Proteins | Zendy

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Allosteric Switches: Remote Controls for Proteins

Author(s) -

Berg Thorsten

Publication year - 2009

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200806169

Subject(s) - allosteric regulation , task (project management) , domain (mathematical analysis) , control (management) , computer science , signaling proteins , computational biology , chemistry , microbiology and biotechnology , biology , artificial intelligence , biochemistry , engineering , mathematics , signal transduction , receptor , mathematical analysis , systems engineering

Long‐distance service : Finding a selective small‐molecule modulator for every domain of every human protein is a Herculean task. Wouldn't it be much easier to control the activity of any protein of choice by simply fusing it with a generally adaptable switch protein and controlling protein activity indirectly?

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