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Coupling Microdroplet Microreactors with Mass Spectrometry: Reading the Contents of Single Droplets Online
Author(s) -
Fidalgo Luis M.,
Whyte Graeme,
Ruotolo Brandon T.,
Benesch Justin L. P.,
Stengel Florian,
Abell Chris,
Robinson Carol V.,
Huck Wilhelm T. S.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200806103
Subject(s) - microreactor , mass spectrometry , microfluidics , coupling (piping) , nanotechnology , chemistry , microfluidic chip , bar (unit) , lab on a chip , analytical chemistry (journal) , materials science , chromatography , physics , organic chemistry , meteorology , metallurgy , catalysis
Abstract Fully integrated : Mass spectrometry has been integrated into a detection scheme for microdroplets that are created within microfluidic channels (see picture, scale bar 200 μm). This technique allows droplets to be identified based on the compounds they contain, and combines fluorescence screening with MS analysis. These experiments indicate how similar approaches can be applied to the ambitious goals of on‐chip protein evolution and chemical synthesis.