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Mass Spectrometry Assisted Lithography for the Patterning of Cell Adhesion Ligands on Self‐Assembled Monolayers
Author(s) -
Kim YoungKwan,
Ryoo SooRyoon,
Kwack SulJin,
Min DalHee
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200806098
Subject(s) - monolayer , adhesion , substrate (aquarium) , self assembled monolayer , cell adhesion , nanotechnology , maleimide , self assembly , chemistry , materials science , mass spectrometry , polymer chemistry , organic chemistry , chromatography , oceanography , geology
Pattern of events : A simple and flexible method has been developed for patterning cell adhesion ligands. Locally erasing self‐assembled monolayers with tri(ethyleneglycol) groups on a gold substrate by using a MALDI‐TOF MS nitrogen laser and filling the exposed gold surface with an alkanethiol presenting carboxylic acid groups enables subsequent immobilization of maleimide and a cell adhesion peptide, which can then recognize cells (see scheme).