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Multicomponent Reactions for the Synthesis of Complex Piperidine Scaffolds
Author(s) -
Zhu Wei,
Mena Marisa,
Jnoff Eric,
Sun Na,
Pasau Patrick,
Ghosez Léon
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200806065
Subject(s) - piperidine , diversity (politics) , intramolecular force , computer science , chemistry , combinatorial chemistry , organic chemistry , political science , law
Creating diversity : Multicomponent reactions for the synthesis of complex piperidine scaffolds lead to high levels of skeletal, functional, and stereochemical diversity in an efficient way (see scheme, X=OR, NR 2 ). Connecting the acid chloride component to the dienophile generates polycyclic piperidine scaffolds by an intramolecular Diels–Alder reaction of the in situ generated azadienes.