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Selective CF Bond Activation of Tetrafluorobenzenes by Nickel(0) with a Nitrogen Donor Analogous to N‐Heterocyclic Carbenes
Author(s) -
Doster Meghan E.,
Johnson Samuel A.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200806048
Subject(s) - nickel , chemistry , nitrogen , hexa , ligand (biochemistry) , oxidative addition , transition metal , medicinal chemistry , stereochemistry , photochemistry , combinatorial chemistry , catalysis , organic chemistry , biochemistry , receptor
N, not NHC : A neutral, basic, strong σ‐donor nitrogen ancillary ligand with properties analogous to those of N‐heterocyclic carbenes (NHCs) was developed to aid in the oxidative additions of challenging substrates to late transition metals. Selective, room‐temperature CF bond activation was observed with hexa‐, penta‐, and all three isomers of tetrafluorobenzene using a nickel(0) source in the presence of this donor.