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Icosahedral DNA Nanocapsules by Modular Assembly
Author(s) -
Bhatia Dhiraj,
Mehtab Shabana,
Krishnan Ramya,
Indi Shantinath S.,
Basu Atanu,
Krishnan Yamuna
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200806000
Subject(s) - icosahedral symmetry , nanocapsules , nanotechnology , dna , polyhedron , modular design , materials science , colloidal gold , dna origami , self assembly , crystallography , nanoparticle , chemistry , computer science , nanostructure , mathematics , biochemistry , combinatorics , operating system
It's a trap! DNA polyhedra formed through molecular self‐assembly may function as nanocapsules for the targeted delivery of encapsulated entities. This functional aspect was demonstrated for the most complex DNA‐based platonic solid: During the stepwise amalgamation of discrete polyhedra to form icosahedra, gold nanoparticles (GNPs) were encapsulated from solution (see illustration and TEM image of icosahedral cages containing GNPs).