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A Stable Homodinuclear Biscobalt(III)–Schiff Base Complex for Catalytic Asymmetric 1,4‐Addition Reactions of β‐Keto Esters to Alkynones
Author(s) -
Chen Zhihua,
Furutachi Makoto,
Kato Yuko,
Matsunaga Shigeki,
Shibasaki Masakatsu
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200805967
Subject(s) - chemistry , catalysis , schiff base , solvent , base (topology) , moisture , inorganic chemistry , medicinal chemistry , polymer chemistry , organic chemistry , mathematics , mathematical analysis
Two metal cooperation : A homodinuclear Co 2 –Schiff base complex Co 2 (OAc) 2 – 1 promoted the asymmetric 1,4‐addition of β‐keto esters to alkynones under solvent‐free conditions in air (see scheme). The reactions proceeded without air or moisture sensitivity in high yields and with high enantioselectivities (99–91 % ee ) at room temperature under highly concentrated conditions (neat–20 M ) with 0.1–2.5 mol % catalyst loading.