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Molecular Photoacoustic Tomography with Colloidal Nanobeacons
Author(s) -
Pan Dipanjan,
Pramanik Manojit,
Senpan Angana,
Yang Xinmai,
Song Kwang H.,
Scott Mike J.,
Zhang Huiying,
Gaffney Patrick J.,
Wickline Samuel A.,
Wang Lihong V.,
Lanza Gregory M.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200805947
Subject(s) - photoacoustic imaging in biomedicine , tomography , biomedical engineering , radiology , photoacoustic spectroscopy , feature (linguistics) , fibrin , medicine , photoacoustic tomography , materials science , optics , physics , linguistics , philosophy , immunology
Spotting clots : Vascularly constrained colloidal gold nanobeacons (GNBs; see picture) can be used as exogenous photoacoustic contrast agents for the targeted detection of fibrin, a major biochemical feature of thrombus. Fibrin‐targeted GNBs provide a more than tenfold signal enhancement in photoacoustic tomography in the near‐IR wavelength window, indicating their potential for diagnostic imaging.