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Efficient Catalytic Promiscuity for Chemically Distinct Reactions
Author(s) -
Babtie Ann C.,
Bandyopadhyay Subhajit,
Olguin Luis F.,
Hollfelder Florian
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200805843
Subject(s) - promiscuity , catalysis , chemistry , combinatorial chemistry , biochemistry , biology , ecology
High catalytic proficiencies observed for the native and promiscuous reaction of the Pseudomonas aeruginosa arylsulfatase (PAS; the picture shows transition states of the two substrates with corresponding binding constants K tx ) suggest that the trade‐off between high activity and tight specificity can be substantially relaxed.