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Biotin–Avidin as a Protease‐Responsive Cap System for Controlled Guest Release from Colloidal Mesoporous Silica
Author(s) -
Schlossbauer Axel,
Kecht Johann,
Bein Thomas
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200805818
Subject(s) - avidin , biotinylation , biotin , mesoporous silica , chemistry , streptavidin , protease , colloid , nanotechnology , drug delivery , mesoporous material , moiety , biophysics , combinatorial chemistry , biochemistry , enzyme , organic chemistry , materials science , catalysis , biology
Tell your guests when it's time to go : When avidin caps are attached to biotinylated colloidal mesoporous silica, the four subunits of the protein avidin can each bind to a biotin moiety attached to the surface (see picture). The resulting material is a promising candidate for the design of smart detergents or drug‐delivery systems. The caps can be opened to release guest molecules by controlled enzymatic hydrolysis of the protein.