Premium
Catalytic Asymmetric Cycloaddition of Ketenes and Nitroso Compounds: Enantioselective Synthesis of α‐Hydroxycarboxylic Acid Derivatives
Author(s) -
Dochnahl Maximilian,
Fu Gregory C.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200805805
Subject(s) - enantioselective synthesis , regioselectivity , cycloaddition , catalysis , nitroso , chemistry , organic chemistry , combinatorial chemistry , nitroso compounds
Abstract The appropriate choice of chiral catalyst and starting materials leads to the synthesis of 1,2‐oxazetidin‐3‐ones by cycloadditions of ketenes with nitroso compounds with very good regioselectivity and enantioselectivity. In addition to serving as potentially bioactive target molecules, the products can be transformed into other important classes of compounds, such as α‐hydroxycarboxylic acid derivatives.