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Exploiting the Divergent Reactivity of Aryl–Palladium Intermediates for the Rapid Assembly of Fluorene and Phenanthrene Derivatives
Author(s) -
Zhao YaBin,
Mariampillai Brian,
Candito David A.,
Laleu Benoît,
Li Mengzhou,
Lautens Mark
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200805780
Subject(s) - fluorene , phenanthrene , reactivity (psychology) , palladium , domino , aryl , chemistry , combinatorial chemistry , photochemistry , organic chemistry , catalysis , medicine , alkyl , alternative medicine , pathology , polymer
They all fall down : The value of domino processes can be greatly enhanced when the possibility exists for one to selectively diverge from a common intermediate. In preliminary studies the dual reactivity of aryl–palladium intermediates is exploited. A diverse array of fluorene and phenanthrene derivatives were synthesized in a rapid and efficient manner (see scheme).