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Synthesis and Microcontact Printing of Dual End‐Functionalized Mucin‐like Glycopolymers for Microarray Applications
Author(s) -
Godula Kamil,
Rabuka David,
Nam Ki Tae,
Bertozzi Carolyn R.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200805756
Subject(s) - microcontact printing , click chemistry , mucin , fluorophore , materials science , nanotechnology , polydimethylsiloxane , chemistry , polymer chemistry , fluorescence , biochemistry , physics , quantum mechanics
Abstract Click to view : Glycopolymers can be used to display glycans on microarrays in native‐like architectures. The structurally uniform alkyne‐terminated mucin mimetic glycopolymers (see picture; TR=fluorophore) were printed on azide‐functionalized chips by microcontact printing in the presence of a copper catalyst. The surface‐bound glycopolymers bind lectins in a ligand‐specific manner.