Synthesis and Microcontact Printing of Dual End‐Functionalized Mucin‐like Glycopolymers for Microarray Applications | Zendy

Godula Kamil | Zendy; Rabuka David | Zendy; Nam Ki Tae | Zendy; Bertozzi Carolyn R. | Zendy

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Synthesis and Microcontact Printing of Dual End‐Functionalized Mucin‐like Glycopolymers for Microarray Applications

Author(s) -

Godula Kamil,

Rabuka David,

Nam Ki Tae,

Bertozzi Carolyn R.

Publication year - 2009

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200805756

Subject(s) - microcontact printing , click chemistry , mucin , fluorophore , materials science , nanotechnology , polydimethylsiloxane , chemistry , polymer chemistry , fluorescence , biochemistry , physics , quantum mechanics

Click to view : Glycopolymers can be used to display glycans on microarrays in native‐like architectures. The structurally uniform alkyne‐terminated mucin mimetic glycopolymers (see picture; TR=fluorophore) were printed on azide‐functionalized chips by microcontact printing in the presence of a copper catalyst. The surface‐bound glycopolymers bind lectins in a ligand‐specific manner.

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