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Fluorescence Signal Amplification by Cation Exchange in Ionic Nanocrystals
Author(s) -
Li Jishan,
Zhang Tierui,
Ge Jianping,
Yin Yadong,
Zhong Wenwan
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200805710
Subject(s) - fluorescence , divalent , detection limit , nanocrystal , ionic bonding , chemistry , ion exchange , signal (programming language) , ionic liquid , photochemistry , analytical chemistry (journal) , materials science , nanotechnology , ion , optics , chromatography , computer science , physics , catalysis , organic chemistry , programming language
Abstract Lighting‐up time : A cation‐exchange reaction releases thousands of divalent cations from nonfluorescent CdSe ionic crystals and triggers fluorescence from thousands of originally nonfluorescent Fluo‐4 fluorophores to obtain a large fluorescence amplification (see picture) and a low detection limit in bioassays. The technique is fast, simple, with a large dye‐to‐reporter labeling ratio, and flexible in selection of nanocrystals and fluorophores.