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Oxindole Synthesis by Direct Coupling of C sp 2 H and C sp 3 H Centers
Author(s) -
Jia YiXia,
Kündig E. Peter
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200805652
Subject(s) - intramolecular force , oxindole , chemistry , coupling (piping) , oxidative coupling of methane , combinatorial chemistry , stereochemistry , organic chemistry , materials science , catalysis , metallurgy
An sp 2 /sp 3 get‐together : A novel and efficient method can be used to synthesize 3,3‐disubstitued oxindoles by the direct intramolecular oxidative coupling of an aryl C sp 2H and a C sp 3H center (see scheme; DMF= N , N ‐dimethylformamide).