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Lighting up H 2 O 2 : The Molecule that Is a “Necessary Evil” in the Cell
Author(s) -
Zhao Wei
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200805651
Subject(s) - hydrogen peroxide , fluorescence , chemistry , mitochondrion , molecule , living cell , photochemistry , biophysics , biochemistry , biology , optics , organic chemistry , microbiology and biotechnology , physics
A cunning plan : In the multifunctional fluorescent probe MitoPY1 the phosphonium head group (red) targets mitochondria and the boronate group (green) responds to hydrogen peroxide. MitoPY1 reacts selectively with mitochondrial H 2 O 2 in living cells, and an increase in fluorescence is triggered by the conversion of MitoPY1 into MitoPY1ox (yellow).