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Engineering Bisquinolinium/Thiazole Orange Conjugates for Fluorescent Sensing of G‐Quadruplex DNA
Author(s) -
Yang Peng,
De Cian Anne,
TeuladeFichou MariePaule,
Mergny JeanLouis,
Monchaud David
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200805613
Subject(s) - g quadruplex , linker , fluorescence , conjugate , förster resonance energy transfer , dna , chemistry , guanine , thiazole , combinatorial chemistry , biophysics , nanotechnology , materials science , stereochemistry , biochemistry , computer science , biology , gene , optics , mathematical analysis , nucleotide , physics , mathematics , operating system
Abstract Lighting up : A G‐quadruplex‐specific fluorescent probe was designed combining the specificity of the pyridodicarboxamide motif for guanine quadruplexes and the fluorescence properties of thiazole orange. While the assembly of the two partners through a flexible linker leads to a nonselective probe, merging them in a single, rigid scaffold leads to a dye that elicits the properties required for G‐quadruplex sensing.