Enantioselective Intermolecular Crossed‐Conjugate Additions between Nitroalkenes and α,β‐Enals through a Dual Activation Strategy | Zendy

Zhong Cheng | Zendy; Chen Yunfeng | Zendy; Petersen Jeffrey L. | Zendy; Akhmedov Novruz G. | Zendy; Shi Xiaodong | Zendy

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Enantioselective Intermolecular Crossed‐Conjugate Additions between Nitroalkenes and α,β‐Enals through a Dual Activation Strategy

Author(s) -

Zhong Cheng,

Chen Yunfeng,

Petersen Jeffrey L.,

Akhmedov Novruz G.,

Shi Xiaodong

Publication year - 2009

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200805558

Subject(s) - pyrrolidine , conjugate , enantioselective synthesis , dual (grammatical number) , intermolecular force , chemistry , enantiomer , iminium , combinatorial chemistry , lewis acids and bases , base (topology) , stereochemistry , catalysis , organic chemistry , mathematics , molecule , philosophy , mathematical analysis , linguistics

Double the fun : The title reaction was developed by using a Lewis base/iminium activation strategy (see scheme). The reaction proceeded with excellent yields and ee values, and the products were additionally transformed into a single enantiomer of a substituted pyrrolidine with excellent retention of configuration.

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