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Catalytic, Enantioselective Ring Opening of Aziridines
Author(s) -
Schneider Christoph
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200805542
Subject(s) - enantioselective synthesis , bimetallic strip , nucleophile , catalysis , ring (chemistry) , silylation , trimethylsilyl , chemistry , combinatorial chemistry , organic chemistry
Cooperative metal centers in a bimetallic catalyst facilitate the highly enantioselective ring opening of meso aziridines 1 with silyl nucleophiles (see scheme; TMS=trimethylsilyl). The 1,2‐azidoamides 2 and 1,2‐amidonitriles 3 obtained in this way in high yields and with up to 99 % ee are valuable precursors to enantiomerically pure 1,2‐diamines and β‐amino acids.
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