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Receptor‐Mediated Targeting of Cathepsins in Professional Antigen Presenting Cells
Author(s) -
Hillaert Ulrik,
Verdoes Martijn,
Florea Bogdan I.,
Saragliadis Anastasios,
Habets Kim L. L.,
Kuiper Johan,
Van Calenbergh Serge,
Ossendorp Ferry,
van der Marel Gijsbert A.,
Driessen Christoph,
Overkleeft Hermen S.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200805529
Subject(s) - receptor , chemistry , antigen , mannose receptor , mannose , modular design , microbiology and biotechnology , cathepsin , biochemistry , biophysics , computational biology , biology , immunology , computer science , in vitro , enzyme , macrophage , operating system
Tag for professionals : A fluorescently tagged clustered mannoside DCG‐04 analogue (see structure) is designed and synthesized using a modular approach. Uptake of the probe in professional antigen presenting cells and subsequent labeling of cathepsins proceeded in a mannose‐receptor dependent manner.