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Antagomirzymes: Oligonucleotide Enzymes That Specifically Silence MicroRNA Function
Author(s) -
Jadhav Vaibhav M.,
Scaria Vinod,
Maiti Souvik
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200805521
Subject(s) - microrna , gene knockdown , oligonucleotide , function (biology) , nucleic acid , biology , computational biology , rna , long non coding rna , microbiology and biotechnology , genetics , gene
Many important cellular processes are regulated by small endogenous noncoding RNAs known as microRNAs (miRNAs). The precise molecular function of many miRNAs is unknown; different loss‐of‐function methods are required to gain insight into the biology of these small RNA molecules. Nucleic acid enzymes termed antagomirzymes are now shown to be valuable tools for the specific knockdown of miRNA in vitro and in vivo (see scheme).