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A Palladium(II)‐Catalyzed Synthesis of Spiroacetals through a One‐Pot Multicomponent Cascade Reaction
Author(s) -
Barluenga José,
Mendoza Abraham,
Rodríguez Félix,
Fañanás Francisco J.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200805519
Subject(s) - palladium , cascade , catalysis , chemistry , component (thermodynamics) , combinatorial chemistry , coupling reaction , coupling (piping) , cascade reaction , organic chemistry , materials science , physics , chromatography , thermodynamics , metallurgy
Functionalized spiroacetals have been easily prepared in a one‐pot three‐component coupling process that involves the reaction of pentynol derivatives, salicylaldehydes, and amines in the presence of catalytic amounts of a palladium(II) complex (see scheme). Alternatively, oxygen‐substituted spiroacetals can be obtained by using orthoesters as the third component.