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De Novo Design of a βαβ Motif
Author(s) -
Liang Huanhuan,
Chen Hao,
Fan Keqiang,
Wei Ping,
Guo Xianrong,
Jin Changwen,
Zeng Chen,
Tang Chao,
Lai Luhua
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200805476
Subject(s) - motif (music) , computational biology , biology , art , aesthetics
A designer monomeric protein with a βαβ fold—two parallel β strands connected by an α helix (see structure)—was constructed solely from coded amino acids. The high thermal stability of the structure is due to a large extent to tryptophan–tryptophan interactions between the two β strands.
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