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Oxidase‐Like Activity of Polymer‐Coated Cerium Oxide Nanoparticles
Author(s) -
Asati Atul,
Santra Santimukul,
Kaittanis Charalambos,
Nath Sudip,
Perez J. Manuel
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200805279
Subject(s) - cerium oxide , nanoparticle , catalysis , cerium , chemistry , polymer , redox , combinatorial chemistry , oxidase test , iron oxide nanoparticles , inorganic chemistry , enzyme , nuclear chemistry , photochemistry , polymer chemistry , nanotechnology , organic chemistry , materials science
Inorganic enzyme? Ceria nanoparticles exhibit unique oxidase‐like activity at acidic pH values. These redox catalysts can be used in immunoassays (ELISA) when modified with targeting ligands (see picture; light blue and yellow structures are nanoparticles with attached ligands). This modification allows both for binding and for detection by the catalytic oxidation of sensitive colorimetric dyes (e.g. TMB).