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Total Synthesis of (−)‐Amphidinolide K
Author(s) -
Ko Haye Min,
Lee Chung Whan,
Kwon Hyung Kyoo,
Chung Hea Seung,
Choi Soo Young,
Chung Young Keun,
Lee Eun
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200805266
Subject(s) - chemistry , alkene , metathesis , total synthesis , stereochemistry , enyne metathesis , derivative (finance) , salt metathesis reaction , enyne , organic chemistry , catalysis , financial economics , economics , polymerization , polymer
Macrolide magic : An enyne cross‐metathesis reaction of an alkynyl boronate with an alkene derivative as well as a radical cyclization reaction of a homopropargylic β‐alkoxyacrylate are the key transformations in the total synthesis of the cytotoxic macrolide (−)‐amphidinolide K.
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