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Pattern‐Based Recognition of Heparin Contaminants by an Array of Self‐Assembling Fluorescent Receptors
Author(s) -
Jagt Richard B. C.,
GómezBiagi Rodolfo F.,
Nitz Mark
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200805238
Subject(s) - fluorescence , receptor , heparin , contamination , chemistry , nanotechnology , environmental science , computer science , biochemistry , biology , materials science , ecology , optics , physics
Abstract Tracking down potential killers : Strong host–guest interactions enable the facile combination of polycationic cyclodextrin binding motifs (blue) with fluorescent reporters (orange) tethered to a hydrophobic guest molecule (dark green). An array of supramolecular fluorescent receptors prepared by this modular approach was used for the pattern‐based recognition of negatively charged contaminants in the anticoagulant drug heparin.