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Plug‐Based Microfluidics with Defined Surface Chemistry to Miniaturize and Control Aggregation of Amyloidogenic Peptides
Author(s) -
Meier Matthias,
KennedyDarling Julia,
Choi Se Hoon,
Norstrom Eric M.,
Sisodia Sangram S.,
Ismagilov Rustem F.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200805225
Subject(s) - microfluidics , miniaturization , nanotechnology , schematic , chemistry , biophysics , materials science , engineering , biology , electronic engineering
Small with control : For miniaturization of protein aggregation experiments the interfacial chemistry must be controlled to avoid protein aggregation caused by interfacial adsorption. Plug‐based microfluidics with defined surface chemistry (see schematic picture) can then be used to perform hundreds of aggregation experiments with volume‐limited samples, such as cerebrospinal fluid from mice.