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Enantioselective Synthesis of P‐Stereogenic Phosphinates and Phosphine Oxides by Molybdenum‐Catalyzed Asymmetric Ring‐Closing Metathesis
Author(s) -
Harvey James Stephen,
Malcolmson Steven J.,
Dunne Katherine S.,
Meek Simon J.,
Thompson Amber L.,
Schrock Richard R.,
Hoveyda Amir H.,
Gouverneur Véronique
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200805066
Subject(s) - enantioselective synthesis , stereocenter , molybdenum , catalysis , phosphine , ring closing metathesis , metathesis , chemistry , stereochemistry , combinatorial chemistry , organic chemistry , polymerization , polymer
The first catalytic route toward the title compounds by asymmetric ring‐closing metathesis is described. A remarkable reversal of enantioselectivity is observed when the achiral imido ligand of the chiral molybdenum‐catalyst is changed (see scheme), thus highlighting the importance of the achiral and the chiral ligands in catalyst design.