Efficient Synthesis of Chiral β‐Arylisopropylamines by Using Catalytic Asymmetric Hydrogenation | Zendy

Chen Jian | Zendy; Zhang Weicheng | Zendy; Geng Huiling | Zendy; Li Wei | Zendy; Hou Guohua | Zendy; Lei Aiwen | Zendy; Zhang Xumu | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Efficient Synthesis of Chiral β‐Arylisopropylamines by Using Catalytic Asymmetric Hydrogenation

Author(s) -

Chen Jian,

Zhang Weicheng,

Geng Huiling,

Li Wei,

Hou Guohua,

Lei Aiwen,

Zhang Xumu

Publication year - 2009

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200805058

Subject(s) - catalysis , acetamide , condensation , combinatorial chemistry , chemistry , catalytic hydrogenation , asymmetric hydrogenation , organic chemistry , enantioselective synthesis , physics , thermodynamics

Direct condensation of β‐arylketones with acetamide afforded both Z and E enamides. The Z ‐configured substrates underwent hydrogenation with excellent enantioselectivity by using the Rh/tangphos catalytic system (see scheme; tangphos=1,1′‐di‐ tert ‐butyl‐[2,2′]‐diphospholanyl). The product β‐arylisopropylamines are important precursors to several drugs.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research