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Metal‐Ion Selectivity of Chemically Modified Uracil Pairs in DNA Duplexes
Author(s) -
Okamoto Itaru,
Iwamoto Kenji,
Watanabe Yuko,
Miyake Yoko,
Ono Akira
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200804952
Subject(s) - uracil , selectivity , chemistry , dna , metal ions in aqueous solution , metal , ion , inorganic chemistry , combinatorial chemistry , organic chemistry , biochemistry , catalysis
Abstract DNA duplexes containing 5‐modified uracil pairs (5‐bromo, 5‐fluoro, and 5‐cyanouracil) bind selectivity to metal ions. Their selectivity is sensitive to the pH value of the solution (see picture), as the acidities of the modified uracil bases vary according to the electron‐withdrawing properties of the substituents.