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Exceptional Selectivity in Cyclopropanation Reactions Catalyzed by Chiral Cobalt(II)–Porphyrin Catalysts
Author(s) -
Doyle Michael P.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200804940
Subject(s) - cyclopropanation , porphyrin , catalysis , cobalt , olefin fiber , chemistry , selectivity , photochemistry , combinatorial chemistry , organic chemistry
Toss the olefin into the porphyrin : The development of chiral cobalt(II)–porphyrin catalysts by straightforward coupling processes has made possible the additions of diazocarbonyl compounds to a broad spectrum of olefins to access functionalized cylopropanes. The cyclopropanation reactions demonstrate high product yields, exceptional diastereoselectivity, and excellent enantiocontrol.