Premium
Practical Imidazole‐Based Phosphine Ligands for Selective Palladium‐Catalyzed Hydroxylation of Aryl Halides
Author(s) -
Schulz Thomas,
Torborg Christian,
Schäffner Benjamin,
Huang Jun,
Zapf Alexander,
Kadyrov Renat,
Börner Armin,
Beller Matthias
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200804898
Subject(s) - phosphine , palladium , aryl , hydroxylation , imidazole , halide , chemistry , combinatorial chemistry , aryl halide , organic chemistry , catalysis , alkyl , enzyme
The phenol countdown : Novel imidazole‐based phosphine ligands are synthesized on scales up to 100 g by a convenient lithiation–phosphorylation method. The phosphines are stable towards air and moisture and are successfully applied as ligands in the palladium‐catalyzed selective hydroxylation of aryl halides (see scheme, dba=dibenzylideneacetone).