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Catalytic Asymmetric Cross‐Couplings of Racemic α‐Bromoketones with Arylzinc Reagents
Author(s) -
Lundin Pamela M.,
Esquivias Jorge,
Fu Gregory C.
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200804888
Subject(s) - stereocenter , aryl , chemistry , combinatorial chemistry , reagent , catalysis , substituent , electrophile , enantioselective synthesis , organic chemistry , alkyl
Nickel box : The first catalytic asymmetric method for cross‐coupling arylzinc reagents with α‐bromoketones has been developed (see scheme). This stereoconvergent carbon–carbon bond‐forming process occurs under unusually mild conditions and without activators, thereby allowing the generation of potentially labile tertiary stereocenters.