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Protein Recognition by an Ensemble of Fluorescent DNA G‐Quadruplexes
Author(s) -
Margulies David,
Hamilton Andrew D.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200804887
Subject(s) - g quadruplex , computational biology , dna , chemistry , computer science , biology , biochemistry
Sniffing out proteins : Fluorescent DNA G‐quadruplexes have been used for building versatile signaling receptors for proteins in a single solution. Introducing a protein sample to the ensemble results in a unique emission signature for unambiguous identification (see scheme, R=fluorophore). The self‐assembled, pattern‐based protein detection systems are easily fabricated, have the potential for high‐throughput operations, and have the ability to handle small protein samples.