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High‐Yielding Synthesis of the Anti‐Influenza Neuramidase Inhibitor (−)‐Oseltamivir by Three “One‐Pot” Operations
Author(s) -
Ishikawa Hayato,
Suzuki Takaki,
Hayashi Yujiro
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200804883
Taking shortcuts : A remarkably short and high‐yielding asymmetric total synthesis of (−)‐oseltamivir takes advantage of organocatalysis and single‐pot domino operations. The target, known as the drug Tamiflu, is prepared efficiently in a short time, and also its derivatives can be synthesized effectively.