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Self‐Assembly of a Four‐Helix Bundle on a DNA Quadruplex
Author(s) -
Rosenzweig Brooke A.,
Hamilton Andrew D.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200804849
Subject(s) - helix bundle , helix (gastropod) , guanine , g quadruplex , monomer , dna , amphiphile , chemistry , scaffold , peptide , crystallography , biophysics , nucleic acid , combinatorial chemistry , stereochemistry , biochemistry , protein structure , biology , polymer , copolymer , organic chemistry , nucleotide , gene , snail , medicine , ecology , biomedical engineering
Come together : A novel method for assembling monomers and controlling structure of a de novo helix bundle protein is described. A guanine (G)‐rich oligodeoxynucleotide scaffold forms a hydrogen‐bonded DNA quadruplex in the presence of potassium counterions, thereby inducing a helical structure and fourfold stoichiometry in conjugated, amphiphilic peptide sequences. The DNA scaffold shows potential for rapidly assembling designed proteins.