Semisynthesis of a Homogeneous Glycoprotein Enzyme: Ribonuclease C: Part 1 | Zendy

Piontek Christian | Zendy; Ring Petra | Zendy; Harjes Olaf | Zendy; Heinlein Christian | Zendy; Mezzato Stefano | Zendy; Lombaelson | Zendy; Pöhner Claudia | Zendy; Püttner Markus | Zendy; Varón Silva Daniel | Zendy; Martin Andreas | Zendy; Schmid Franz Xaver | Zendy; Unverzagt Carlo | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Semisynthesis of a Homogeneous Glycoprotein Enzyme: Ribonuclease C: Part 1

Author(s) -

Piontek Christian,

Ring Petra,

Harjes Olaf,

Heinlein Christian,

Mezzato Stefano,

Lombaelson,

Pöhner Claudia,

Püttner Markus,

Varón Silva Daniel,

Martin Andreas,

Schmid Franz Xaver,

Unverzagt Carlo

Publication year - 2009

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200804734

Subject(s) - semisynthesis , ribonuclease , glycoprotein , homogeneous , enzyme , biochemistry , chemistry , microbiology and biotechnology , biology , rna , mathematics , gene , combinatorics

Seven in one blow : The efficient formation of mixed disulfides on the thiol‐rich fusion protein A followed by subsequent intein cleavage gave the fragment B with all seven cysteines protected against oxidation. The native chemical ligation of B with synthetic glycopeptide thioesters provides glycoproteins.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research