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A Phosphine‐Mediated Conversion of Azides into Diazo Compounds
Author(s) -
Myers Eddie L.,
Raines Ronald T.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200804689
Subject(s) - diazo , triazene , chemistry , phosphine , combinatorial chemistry , azide , staudinger reaction , organic chemistry , catalysis
N2 the mild : Diazo compounds are extremely versatile intermediates for synthetic organic chemistry, but their synthesis can be challenging in the presence of delicate functional groups. The Staudinger ligation has inspired a mild method for the conversion of a broad range of azides into their diazo compound derivatives through an acyl triazene intermediate.