Palladium‐Catalyzed Annulation of Acyloximes with Arynes (or Alkynes): Synthesis of Phenanthridines and Isoquinolines | Zendy

Gerfaud Thibaud | Zendy; Neuville Luc | Zendy; Zhu Jieping | Zendy

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Palladium‐Catalyzed Annulation of Acyloximes with Arynes (or Alkynes): Synthesis of Phenanthridines and Isoquinolines

Author(s) -

Gerfaud Thibaud,

Neuville Luc,

Zhu Jieping

Publication year - 2009

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200804683

Subject(s) - annulation , palladium , aryne , catalysis , chemistry , domino , trimethylsilyl , trifluoromethanesulfonate , surface modification , molecular sieve , solvent , intermolecular force , combinatorial chemistry , organic chemistry , medicinal chemistry , molecule

Intermolecular insertion : A palladium‐catalyzed domino aminopalladation/ CH functionalization sequence has been developed, and provides access to functionalized phenanthridines and isoquinolines (see scheme; Tf=triflate, TMS=trimethylsilyl, M.S.=molecular sieves). The use of butyronitrile as the solvent is determinant to the success of the domino process.

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