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Beyond Reppe: Building Substituted Arenes by [2+2+2] Cycloadditions of Alkynes
Author(s) -
Galan Brandon R.,
Rovis Tomislav
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200804651
Subject(s) - cycloaddition , selectivity , chemistry , transition metal , catalysis , combinatorial chemistry , metal , computational chemistry , medicinal chemistry , organic chemistry
Synthetic sequel : The transition‐metal‐catalyzed [2+2+2] cycloaddition is an established method for the construction of carbocyclic frameworks but is often plagued by poor selectivity. Recent literature paints a promising picture—a more general metal‐catalyzed [2+2+2] cycloaddition can be accomplished intermolecularly using three separate alkynes to furnish highly substituted arenas (see scheme).