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Ruthenium‐Catalyzed Isomerization of Terminal Olefins: Applications to Synthesis
Author(s) -
Donohoe Timothy J.,
O'Riordan Timothy J. C.,
Rosa Carla P.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200804617
Subject(s) - isomerization , ruthenium , catalysis , hydride , propenyl , chemistry , olefin fiber , olefin metathesis , terminal (telecommunication) , metathesis , combinatorial chemistry , organic chemistry , computer science , hydrogen , polymerization , telecommunications , polymer
In, out, olefin about : A ruthenium hydride complex derived from the Grubbs second‐generation metathesis catalyst has proven to be an efficient catalyst for the selective isomerization of terminal olefins to the corresponding propenyl derivatives (see scheme). This methodology has been applied in a number of syntheses to enable access to complex natural products. Cy=cyclohexyl, Mes=mesityl, MOM=methoxymethyl.