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A Photoreactive Ruthenium(II) Complex Tethered to a Guanine‐Containing Oligonucleotide: A Biomolecular Tool that Behaves as a “Seppuku Molecule”
Author(s) -
Le Gac Stéphane,
Rickling Stéphane,
Gerbaux Pascal,
Defrancq Eric,
Moucheron Cécile,
KirschDe Mesmaeker Andrée
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200804503
Subject(s) - ruthenium , oligonucleotide , guanine , molecule , combinatorial chemistry , chemistry , stereochemistry , dna , biochemistry , organic chemistry , nucleotide , catalysis , gene
Self‐destruction : Attachment of a photoreactive Ru II complex to a guanine‐containing oligonucleotide has led to an innovative biomolecular tool for gene silencing studies. This conjugate can be selectively photo‐cross‐linked with its complementary strand but undergoes a self‐inhibition (or “seppuku”) process in the presence of a noncomplementary target (see picture), which is an attractive strategy to avoid undesired secondary photoeffects.