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A Reduced SNARE Model for Membrane Fusion
Author(s) -
Robson Marsden Hana,
Elbers Nina A.,
Bomans Paul H. H.,
Sommerdijk Nico A. J. M.,
Kros Alexander
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200804493
Subject(s) - lipid bilayer fusion , fusion , membrane , liposome , biophysics , chemistry , fusion protein , nanotechnology , microbiology and biotechnology , biological system , materials science , biology , biochemistry , recombinant dna , philosophy , linguistics , gene
Abstract Let's get together : A minimal model system was developed to mimic the SNARE‐protein‐mediated fusion of biological membranes (see picture). Fusion between two populations of liposomes is controlled by a pair of complementary lipidated oligopeptides that form noncovalent coiled‐coil complexes and thereby force the membranes into close proximity to promote fusion. The model system displays the key characteristics of in vivo fusion events.