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Synthesis of Natural‐Product‐Like Molecules with Over Eighty Distinct Scaffolds
Author(s) -
Morton Daniel,
Leach Stuart,
Cordier Christopher,
Warriner Stuart,
Nelson Adam
Publication year - 2008
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200804486
Subject(s) - natural product , natural (archaeology) , product (mathematics) , chemistry , biology , stereochemistry , mathematics , paleontology , geometry
Seeking scaffold diversity : A synthetic approach for the combinatorial variation of the scaffolds of small molecules is described. Using just six basic reaction types, compounds with 84 distinct scaffolds were prepared. The compounds had many natural‐product‐like structural features including rich stereochemistry, heterocyclic and unsaturated ring systems, and dense functionalization.