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Copper‐Catalyzed Asymmetric Michael Addition of Magnesium, Zinc, and Aluminum Organometallic Reagents: Efficient Synthesis of Chiral Molecules
Author(s) -
Thaler Tobias,
Knochel Paul
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200804446
Subject(s) - stereocenter , reagent , chemistry , aryl , catalysis , combinatorial chemistry , zinc , copper , conjugate , magnesium , organometallic chemistry , michael reaction , enantioselective synthesis , molecule , organic chemistry , mathematical analysis , alkyl , mathematics
Choosing the right metal for the job : A broad range of asymmetric conjugate addition reactions are catalyzed efficiently by copper complexes, provided the appropriate organometallic reagent is used. With aluminum reagents, for example, quaternary stereogenic centers with functionalized aryl substituents can be generated with high enantioselectivity (see scheme).