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Enantioselective Desymmetrization of meso ‐Aziridines with TMSN 3 or TMSCN Catalyzed by Discrete Yttrium Complexes
Author(s) -
Wu Bin,
Gallucci Judith C.,
Parquette Jon R.,
RajanBabu T. V.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200804415
Subject(s) - desymmetrization , enantioselective synthesis , yttrium , dimer , catalysis , chemistry , combinatorial chemistry , stereochemistry , organic chemistry , oxide
Y is it so? Dimeric yttrium–salen complexes (see structure; N blue, O red, Y magenta) catalyze the highly enantioselective ring‐opening of meso ‐aziridines by TMSCN and TMSN 3 . To explain the dramatic differences in the selectivity between mono‐ and dimeric catalysts, a dimetallic mechanism based on the solid‐state structure of the dimer is proposed.