Premium
5‐(Pyrrolidin‐2‐yl)tetrazole‐Catalyzed Aldol and Mannich Reactions: Acceleration and Lower Catalyst Loading in a Continuous‐Flow Reactor
Author(s) -
Odedra Arjan,
Seeberger Peter H.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200804407
Subject(s) - aldol reaction , microreactor , catalysis , tetrazole , mannich reaction , chemistry , organocatalysis , derivative (finance) , organic chemistry , enantioselective synthesis , financial economics , economics
Continuous organocatalysis : Fast aldol and Mannich reactions require less catalyst when conducted in a microreactor. A proline tetrazole derivative (5–10 mol %) catalyzes asymmetric aldol reactions between various aromatic aldehydes and ketones in microreactor at 60 °C with reaction times ranging from 10 to 30 min.