5‐(Pyrrolidin‐2‐yl)tetrazole‐Catalyzed Aldol and Mannich Reactions: Acceleration and Lower Catalyst Loading in a Continuous‐Flow Reactor | Zendy

Odedra Arjan | Zendy; Seeberger Peter H. | Zendy

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5‐(Pyrrolidin‐2‐yl)tetrazole‐Catalyzed Aldol and Mannich Reactions: Acceleration and Lower Catalyst Loading in a Continuous‐Flow Reactor

Author(s) -

Odedra Arjan,

Seeberger Peter H.

Publication year - 2009

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200804407

Subject(s) - aldol reaction , microreactor , catalysis , tetrazole , mannich reaction , chemistry , organocatalysis , derivative (finance) , organic chemistry , enantioselective synthesis , financial economics , economics

Continuous organocatalysis : Fast aldol and Mannich reactions require less catalyst when conducted in a microreactor. A proline tetrazole derivative (5–10 mol %) catalyzes asymmetric aldol reactions between various aromatic aldehydes and ketones in microreactor at 60 °C with reaction times ranging from 10 to 30 min.

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